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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c1b021f06ea098e210aa521784d79785db0c4937350a90f3b5952e3a3d8f359' 
  AND token = 'gTSUS4UESI2ZWvS4F+a9MSpZbzqLd7dP0pmayImOvBY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}