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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e8959ec6bee4e0288024dcd787ee5280468ed924634ac1b198284703959a1707' 
  AND token = 'nv2fFYvn1iL7NtrSouOHU47Anz9sSHRdvZ83G4G0Zyc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}