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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1a1b675a1722ca91ebdd63b804c89c4e8a42e2300f4bb54d4248c7408ec6e261' 
  AND token = 'uEdJgSjCjnKrYB2itIKTxI5V0UCWMhKHzJcmyaElXV4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00029

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}