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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '394050303947429106d63195d8a55fc8e5ccb02e59e48b6a63a0ddf1c18e431e' 
  AND token = '+QGL+AO2ev8eZYRbtVHUdgMRBe4xGbzXGGO4LMeoYGM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}