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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ecc43bde5aa31c3916367ec371600ae3c42f0d5e4b244a2531968a2de9b33711' 
  AND token = 'SmP++VNyUbxTlnrNqSTWIUQGCrIbBWZMWI/rW+wa9sg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}