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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4e0f1e4ed4e633b36ae33c0b84d66038b285a7b21bfe07fad3a731ce37238104' 
  AND token = 'iBmgKWl7oBE5TgZcWCiK6EPO+2Zv+4awisKmrkqnCY4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}