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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '25e9bc11f86eacfcb359325aa85d32210ba5b45f5265a1ff304d9c9459d3923d' 
  AND token = '9wuc4Bk/m0YQQzD5Uymg0+Ure3CpRiQWzoFiQJXtjiA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}