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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4a4ec5ee22edf41ce6f373ab3f0a37b69b303abdf8e3958999c0015b4e085156' 
  AND token = 'ThkNfiR6xsk/yhNRQWEuhodgx1sbIT5kc+UKfbRxYAg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}