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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c375d26a72419794cbc0cf7ce4c861361f2de6f9b98ac199e79de50ebe8af18d' 
  AND token = 'HFf2co3/JXJEpEk4n3N2bXAkxQ4cuC/eWrAV9v3Sl3k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}