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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e2e391fb2da513fd69debe46e31e09d19b00dde2952b3024327cf77cf4791872' 
  AND token = 'uQAgns1AukJIRfKh0R05c7CmOUOArYI1JY9ktFZ8xQ0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00033

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}