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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b8eb2a823a79d8017180d1c0c999038f2567a247cb3c0cdd5ea116770b89d644' 
  AND token = 'IFl97gVES4rW/4zJeSTb3K3NUaU5NsQHyjT5pkZcBFc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}