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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ed6a9724627fd2a9f9d279edcb0b2f8e91609bcb1a809a727700d597ec440243' 
  AND token = '5+u3+NHMUICUGg6PwiL73z9uz9c2nTRGqGRLlwvBKcg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}