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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a8743eaed1fbff96d2454de19fce42b695f82eadfcb69f1e7824c2b284de94d1' 
  AND token = 'IxwGlp7BJXfenp0sL5P8XB87spyZb4IsszFgP7Fzqy4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}