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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fd22e455ee6f31108a6aeaa54b0484815fcefb5d9293cac697c697cdb4f23d0a' 
  AND token = 'Uo1QTnHdL3+VmUVBrZCkwrnY2uOErlD9kbUBhBKu6xA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}