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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48a4b121b2c0ab708020c49c07afe9d0f3630d19521e4f3b50a630c811750b28' 
  AND token = '++AYnFokjVZ4w9EUqwF3mTns7eZWA4rb0gEJFsFoJhM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}