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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4baade7e161ce903c0c49efa229a1ed81f2b2864a210af3d6a53aa1f7c8a98f' 
  AND token = 'GTtgyjXX5lh4v+14/fkOCnlJjNMbRhL/kMRCU+2LrF0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}