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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f4d85dfb51c6392b467a49f7f8e53bf6caf33c3d7f6ed77b9d4c049afcdb0f57' 
  AND token = 'kdmVDDx8SSXcpRjza+V2KDFYbfPhq5UYVP9bO7hJl8s=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}