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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d1d4b0484a61fedb27e5e812c58517bc6b510802236e771b6a9c23e5ddc82e1' 
  AND token = '+RSmWCZkKypoypfKn2e6YidaAe7vUUuHPSC9Rir91HA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}