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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '74de46b58cb9ae31e1911effc1281dc4c888dfa82e8b507c9a9e28087fedd86c' 
  AND token = 'wj5ddF2pZODdmrKvKFz/DU1awAlZe8xKY5b2Rpe6KTI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}