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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8a6b5781372e7dd1a9c1cbe7215c62cb20a0511ed83aae2172aa48b0ea01dda3' 
  AND token = 'IHPNMrusojOrsYD1+TN5IuAmgylD/rtOB74B089mk7E=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}