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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c1394a275d24e435b6fbf720174cdc8e348a784dee01a6f81d253f0f144f340c' 
  AND token = 'eCZ3xPtMgZC9z8+R3cxGEEaGOZ30rKYMvxbfCxQyjoM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}