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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '422c4a95c488f290e5e9a189ce9f425f4981e4e132818bd4652d7a670a213507' 
  AND token = 'LveVC/3KxGDl8Wu44pDFXSulw+DOShVE5WfDkzdRpUE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}