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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '399cce21fd63cc2eb5432a08d307df63ce1807b28c22d1a8f113264dc8780759' 
  AND token = 'JIxtdt3Gdfl5+alSKOLJqoJGvBv8nnd5mnak5u2tW0U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}