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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '77a00fb9500e9523831e6b887843b27d2bbf9a0bd2e7e936d3e6f5703cd10335' 
  AND token = 'uIspNo3Ai+N36DTP7HqnFIp9pcNy5/orJJcYafcwH/Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}