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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd57c9f24900e00dcd402ed3308451bd4caed2ce539ce4c9870b34a9e4936a10f' 
  AND token = 'HoNB15f/d/mLiXLa9/z9ssEEa7Z2dLEjaeaSZkin5ig=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}