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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f4ad089764411f161629525e26664d820ce78c43220493433c1605f57d01c47' 
  AND token = 'wFRPWb+2eCY99YoGXS1R3O5JdU1FRwtFYh1y47r9hO4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}