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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5da242eb6348427fdeaf0bdf9e070e97e01e7cc385388cd2d820ac2fbf9d01fd' 
  AND token = 'FRUYCn7Lw44IbB02GT4Qq4WRXZkX5FBJ10A98MFQqt8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}