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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4378e7de0f7df1774f6ad430b45f0ecc217197c6921055c809c07673ca690909' 
  AND token = 'mHJtg2rVPKiPxEcSYsVPToSHk4nhHD2MksthWGkKoPo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}