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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f3f8e686836e6d4127c27872f8caf2e2f128914243f9184c9625a1a2c3228c21' 
  AND token = 'T7a54NoBzAe3GTa22UHolwexClRilWhLu8bpdcY/Tyg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}