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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '758aacddea76fa870b14400626476e9a015a62c2bd2c3dff0c7db3373a52f42c' 
  AND token = 'MB+MDsyx0khsCbRT0QqQRM8hfRf5IUNwQQqKps1t/uY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00043

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}