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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0de878ba65dd801979a90c2ad9dc4f332280d9a6b96fe7c85a2c1544f1dfe638' 
  AND token = '2VXUoHy/FKKJco99jwjeu1dRlnnUn2oOryfjoHzYnRc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}