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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5f0b1be5e31b3fb619a620241dfc61fc2fcb915d48f3604d0d79997bcca473c0' 
  AND token = 'DfMCpFX1V1+0C+K3qEH5EgfbWaVtUbWNsLP7MlWuOd4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}