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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '46ce20a3558d0fb9378a74022b8ba7bb45e87039e1e5a9c4e4b97f87024bc0d6' 
  AND token = 'XJYkiFI+fMXOpbM9uXk7bQvfHvvdCFyj0r+cWayPuyw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}