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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '00ea049c9fdb8b476c8e19a5a8fc0221f540273e946e11aaf6d011c3ca0d2e0f' 
  AND token = '2FrgcR8iOXOff5UrQSpYjh6fD4bQP4Q/gN0Sh9vIOUM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}