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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '221a5902acdacb2a3880ca30aea529f7b74da243a2aaabd1c6a35450ed1a7616' 
  AND token = 'NHlBgkQEd9aWiNp6Etdy/fWV6wkEJB2LeRZSLX+Hmvw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}