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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '49124b6aada69c0d10e9514e189b3f60f3d08cc2d744120be3e1d0b871cfb00b' 
  AND token = 'Cx9Jl3+KF4m33nhOPXwOg/XeANQDFjqV5uC90k2cDZ8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}