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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f2d1a6444ff50a0a3b49c4d5479ddc635b3f94463420f4155483280cb2b80d43' 
  AND token = 'lSM/JPDTPojbr/zBg0XdVODD6O1Qr5oFjTmP0Eb/LX0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}