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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8c900bea8d37fe99da2d9bf4d549ee24e728b7fafb024f7cfbf0f51d2a729a4f' 
  AND token = '6NGNO9KB2FvyIlIpGATsDR0/unNTx3I0cwPiJDZhgTc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}