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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '108a9559f72180eec21edd30e7fab3f1126f455c6699d9ec65ace10130f94e04' 
  AND token = '0b+5IwUSdIBmrGvXAIWCRAp4kfSLKB99Sz574bZXYlk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}