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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c784ad78d362b185d38cbc7c8986068d007484fc5bfbf00be2a4dc2ad8519125' 
  AND token = 'VSvFNONIbs+8MPFjq+SDDqtu9GYHNnIN8hUbTnxKiIo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}