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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b889069796aa74ee84b7bdb7333155f6dbc7caa247c6797da9c351c423e3e458' 
  AND token = 'kXxQgbTZxyoH14nM8Y6NH1vIpnb1TUlhKRpiDBaTpTg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}