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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5503e8a4d2d711255a72aa60da62669ebab9a5cca3ab890a8b9a85ec62724441' 
  AND token = '2m0pMOsgGj6P2cz4VT/h+FYr9rEJGwNhCmZ5qm5HZr8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}