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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d1cf278c233a69eaebd74f425c1ebed3009581293c2b8b3a0222d991d5e6c80' 
  AND token = 'fmlTB7UyQwi9APD+muRJm7sEaSYcUadYxqW0fGE7SQQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}