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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d666c194a2f48111b6f93f8e9ecaa5206dbad19cd73959b50a66993ada44416' 
  AND token = '3kNmlRWmO/L4WEG40etpKVoNPj+E9FXx8PZsOd7tZUA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}