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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8279ade4de2a46088a5cd7446afc83f39b0573e4fdd671d80d6f2e066101a2ff' 
  AND token = '+zHacA5IUlEoUnFlLR7j81/bbttxN9KDIBbBHbhfSf0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}