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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '9385a62bc4d2a79dcb839f2b4cf6796d81fe575a302747d30154e8f28c996c46' 
  AND token = 'TbAkt5Pv5DCPyUgdNwP9NG7fjHbLlkNWi+5UyMgZATk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}