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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22d710b3e4f14558f4bf3585c3e102a583e5475c517142f121abb82580962721' 
  AND token = 'aG+zYaF9z2W/APkECP9Tb+t3Xl6NRpbdOsUEUn9qYYw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}