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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '36e6c8e3117a54774c3411d1696369d4c890df76c9d1a7b58c30b2609f7c5d06' 
  AND token = 'H9XAu/i0ylzN0UZrEJ3s/HrSdAuCiDsd88x3VlTsGAg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}