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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1fcd3ab83f35bd0b60fe46866a83ba053a55f399d1c00415a643dbdb5393f443' 
  AND token = 'duiH+6LH7jxZP+sxKPsT0VT/3PPAFtWdM2amU9dV1pc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}