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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b4c1b67d3e339ef5eca244f98726643d178273081e64961397cd3ad26c5f09d7' 
  AND token = 'TU1TXIk6i+Zzd2n7f9vdGwB9JpEwmko8uKF0sonACQQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}